Maine Route 201 is a route of vehicle and commercial transportation that stretches from the United States and Canadian border crossing site near Jackman on Route 201 to the I-95 Connector in Fairfield, the most southern community. This route carries heavy tourist traffic from the Quebec Province in Canada as well as heavy commercial transportation of manufactured products to New England and southern States.

U.S. Route 2 traverses Somerset County, which serves as the major east-west Connector Route from the I-95 Connector in Newport / Palmyra through to the White Mountains in New Hampshire and points beyond to Vermont, Up-State New York, and the Province of Ontario, Canada. Commercial, tourist, residential and much Canadian traffic also travels this route from New Brunswick, Canada to western Canadian Provinces.